Senior Project Manager

Company: SonoThera
Location: South San Francisco
Posted on: February 3, 2026

Job Description:

About SonoThera: SonoThera is a venture capital-backed early-stage biopharmaceutical company developing ultra-sound-guided non-viral targeted gene therapies to treat multiple diseases of high unmet need. The Gene Therapy group at SonoThera uses a collaborative, interdisciplinary, and forward-thinking approach to solving many of the current challenges facing genetic medicine discovery and drug development. SonoThera is headquartered in South San Francisco, CA. The role requires being on-site at least 4 days per week. The Role: SonoThera is seeking a highly motivated Senior Project Manager to play a key role in advancing our genetic medicine drug development programs. The Senior Project Manager will bring expertise in both drug development and project management to support research and manufacturing teams and cross-functional stakeholders. Responsibilities include identifying and managing critical project deliverables, dependencies, and milestones, while maintaining accurate tracking of research and nonclinical timelines through dashboards to support effective planning, communication, decision-making, and risk management. This role will require close collaboration with internal and external cross-functional teams, academic and industry collaborators, and consultants. What You Will Do: Lead project planning and execution of research and nonclinical aspects of development programs from early-stage research to early clinical phase. Facilitate cross-functional planning of deliverables and activities across departments to align scope, dependencies, schedules, budget, deliverables, and risk mitigation strategies. Develop and manage detailed project plans that integrate key activities, timelines, and track the critical path aligned with cross-functional stakeholders. Partner with Research and Manufacturing team leads to facilitating team meetings including, development of meeting agendas, meeting minutes, and tracking of cross functional action items. Track budgets, anticipate scope changes, and communicate changes that may impact the project budget to appropriate key stakeholders. Contribute to the creation and use of project management standards, processes, methodologies, and tools. What You Will Bring: BS/BA in Biological Sciences or closely related field of study required; MS, PhD, MBA, or PMP certification is a plus. 8 years of experience in gene therapy drug development. 3-5 years of formal project management experience in biotech, pharma, or life sciences. Proven track record supporting biologic or drug development programs. Demonstrated leadership and ability to work effectively with project teams. Ability to build and foster cross-functional collaborations both internally and externally at SonoThera. Strong proficiency with Smartsheet project management software. Comfortable operating in an agile, rapidly evolving startup environment. Ability to work in a fast-paced, team-oriented environment. Strong planning and organizational skills Startup experience desired Excellent written and verbal communication skills Compensation: The salary range for this position is $150,000 to $175,000 USD per year. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location .

Keywords: SonoThera, San Jose , Senior Project Manager, Science, Research & Development , South San Francisco, California